Targeting the IL-17 Pathway in Inflammatory Disorders by Cong-Qiu Chu

Author:Cong-Qiu Chu
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

4.5 Inflammatory Bowel Disease

Crohn’s disease is a chronic inflammatory bowel disease, which is also associated with extraintestinal manifestations such as peripheral arthritis and/or axial spondylitis. Genomic data have implicated the IL-23 and IL-17/Th17 pathway in /-17 axis in inflammatory bowel disease in general and Crohn’s disease in particular. SNPs in Il23r as well as in genes involved in IL-23 and IL-17 regulation have been reported in Crohn’s disease [34]. IL-17A-producing CD4+ Th17 cells are increased in both peripheral blood and lamina propria of Crohn’s disease [35]. However, conflicting results have been observed in Crohn’s disease when IL-23 is blocked or IL-17A and IL-17RA are blocked (see Chap. 5), that is, blockade of IL-23 is beneficial, while blocking IL-17 signaling either provides no benefit or is detrimental to Crohn’s disease [36–39].

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.